Article

Effects of algae acid oligosaccharide on dopamine release in striatum and amygdala of rats with Parkinson's disease

Algal acid oligosaccharide HS971 is a seaweed extract. Studies have shown that oligosaccharides have protective effects on neuronal damage, and the algae polysaccharides, which are also seaweed extracts, have been experimentally proven to be able to nourish nerve cells and significantly improve the survival rate of cultured nerve cells. In this study, the effects of HS971 on the release of dopamine in striatum and amygdala were observed in Parkinson's model rats prepared with 6-hydroxydopamine, and the regulation of HS971 on the function of dopaminergic neurons in Parkinson's rats was studied.

 

Rats of standard Parkinson's model were randomly divided into two groups. One group was intraperitoneally injected with 5 mg·kg·d- of brown algae acid oligosaccharide HSH971 for 7 days; the other group was intraperitoneally injected with the same volume and time course of normal saline as control. Results After intraperitoneal injection of brown algae acid oligosaccharide HS971 5 mg·kg·d - 7 days, the release of dopamine from the striatum of Parkinson's rats was significantly higher than that of the control group. There was no significant difference in dopamine release between the two groups of healthy striatum. The effect of intraperitoneal injection of brown algae acid oligosaccharide HS971 on the release of dopamine from amygdala is similar to that of striatum. The amount of dopamine released from the amygdaloid nucleus in the HS971 group was significantly higher than that in the saline-controlled group. However, no significant difference was found in the amygdala release from the healthy side of the two groups.

 

This experiment showed that after treatment with HS971, Parkinson's model rats showed a significant increase in dopamine release from the striatum and amygdala, but no significant changes in the healthy side. Therefore, HS971 is important for the repair of dopaminergic neurons after injury. The regulation of HS971 on the release of dopamine from the damaged striatum and amygdala may be related to improving the metabolic function of residual dopaminergic neurons, ie, enhancing dopamine synthase activity or inhibiting dopamine reuptake.

0 Comments
Leave a Comment
Your email address will not be published. Required fields are marked *
Submit Comment
Concact Us Now
Chitosan Oligosaccharide, Alginate Oligosaccharide, Chitosan Oligosaccharide Suppliers - BZ Oligo
Headquarter:Room 806, D&D Fortune Center, No. 182-6 Haier Road, Qingdao 266061, China
You can trust us
We are a professional Manufacturer in China, and we are constantly innovating so that our customers can have better products and services.
© 2018 Gobalsir Inc.    RELATED ARTICLES        SiteMap.html    SiteMap.xml
Marketing Support by Globalsir
Enter your inquiry details, We will reply you in 24 hours.
Name can't be empty
E-mail can't be empty
Company can't be empty
Phone can't be empty
Products can't be empty
Message can't be empty
Verification code error
code
Refill