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Absorption distribution of chitosan oligosaccharide monomers with different degrees of polymerization in mice

BZ Oligo

Chitooligosaccharide was approved as a new food raw material by the National Health and Family Planning Commission in 2014. Chitooligosaccharide has been proven to have many biological activities, such as antioxidant, anti-inflammatory, anti-obesity, anti-tumor, antibacterial, immune regulation, neuroprotection, lowering blood pressure, lowering blood lipids, lowering cholesterol, promoting tissue regeneration, enhancing drugs and DNA The delivery and absorption of calcium, etc., can effectively treat and prevent many life-threatening diseases, such as cancer, heart disease, diabetes, obesity and Alzheimer's disease. Before studying the physiological activity mechanism of chitosan oligosaccharide, it is necessary to clarify the digestion, absorption, distribution and metabolism of chitosan oligosaccharide in vivo. Researchers from the School of Food Science of Jiangnan University prepared fluorescein isothiocyanate-labeled chitosan oligosaccharide monomers and administered them to mice, and analyzed the shells with a degree of polymerization of 2 to 5 with the help of a small animal in vivo optical imaging system and fluorescence quantitative detection. Differences in the absorption profile of oligosaccharide monomers in mice.

The results showed that after the fluorescently labeled chitosan oligosaccharide monomer was administered to mice by gavage for 1 hour, the fluorescence signal in the mice reached a peak value. It is distributed in kidney and liver, secondly in heart and spleen, and a small amount in lung and brain. The peak distribution of chitobiose in and brain was the most, chitotetraose was the second, and chitopentaose was the least. This provides a theoretical basis for the prevention of liver and kidney-related diseases such as fatty liver, liver cancer, and kidney cancer. To clarify the differences in the in vivo absorption distribution of chitosan oligosaccharide monomers with different degrees of polymerization has certain guiding significance for the study of the structure-activity relationship of chitosan oligosaccharide functional activity. The development and application of food functional food is of great significance.

The article is from Wang Bin's "Absorption distribution of chitosan oligosaccharide monomers with different degrees of polymerization in mice"

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