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Treatment of acute radiation enteritis by intragastric administration of chitosan oligosaccharide

BZ Oligo
To explore the feasibility of intragastric administration of chitosan oligosaccharide (COS) in the treatment of acute radiation enteritis (ARE). Methods: Six normal-grade healthy Beagle dogs were selected as the research objects. The ARE model of Beagle dogs was established by irradiation of the abdominal target area with radiation. Dissolve COS in sterile water to make a 5mg/ml solution, and store it in cold storage. From day 4 after irradiation, COS solution was given by intragastric administration every day. Gastrointestinal administration was carried out once every 12 hours, and 120ml of COS solution at room temperature was given to experimental dogs for intragastric administration each time.
 
The symptoms of each experimental dog on the 3rd day of irradiation were observed. Before irradiation, after irradiation, and after treatment, observe and record the body temperature and body weight of Beagle dogs at a fixed time every day. Before irradiation, on the third day of irradiation, and on the eighth day of treatment, the total number of white blood cells, the total number of neutrophils, and C-reactive protein (CRP) of all experimental dogs were collected and compared. On the 3rd day of irradiation and the 8th day of treatment, colonoscopy was performed on all experimental dogs.
 
Experimental results: All experimental dogs had obvious symptoms of RE on the 3rd day after irradiation, and all of them reached grade 2 radiation intestinal injury, including decreased intake, nausea, vomiting, diarrhea, intermittent blood in the stool, etc. On the 8th day of chitosan oligosaccharide administration, the average body weight and body temperature of all experimental dogs basically returned to the level before irradiation. On the third day of irradiation, the total number of white blood cells, total number of neutrophils, and CRP of each experimental dog were higher than those before irradiation; on the eighth day of treatment, the total number of white blood cells and total number of neutrophils of each experimental dog were lower than those on the third day of irradiation. The Vienna proctoscopy score of each experimental dog on the 8th day of treatment was (1.33±0.52) points, which was significantly lower than (6.83±0.75) points on the 3rd day of irradiation. Conclusion: Gavage with oligochitosan solution is effective in improving clinical symptoms, inflammatory indicators, and mucosal inflammation under colonoscopy in experimental dogs with ARE. It preliminarily confirms the safety of oligochitosan and lays a foundation for further mechanism research.
 
The article is from Luo Yayuan's "Feasibility Study on the Treatment of Acute Radiation Enteritis by Oral Administration of Oligochitosan"
 
Disclaimer: The content of the above-mentioned reprinted or quoted articles is only for the purpose of study and research. If there is any discrepancy, it will be corrected immediately.
 
BZ Oligo mainly offer marine oligosaccharide standards and ingredients, containing alginate oligosaccharide, chitosan oligosaccharide, agar oligosaccharide and carrageenan oligosaccharide, which give business opportunities using these untapped oligosaccharides for biological applications targeting lab research, pharmacy, dietary supplement, sustainable agriculture and animal health. 

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