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Research progress of chitosan in gastric ulcer medicine

BZ Oligo

1. Antiacid treatment

Chitosan can be used as a potential natural anti-gastric acid drug. On the one hand, because chitosan is the only basic polysaccharide existing in nature, the pKa value of its hydrolyzed product D-glucosamine residue is about 6.2 to 7.0. It can be neutralized with acid; at the same time, it is a biopolar macromolecule, which can adsorb part of H+, obviously inhibiting gastric acid. On the other hand, after being dissolved in gastric acid, chitosan can form a protective film in the stomach, covering the surface of the gastric mucosa, further inhibiting the secretion of gastric acid and reducing the activity of pepsin, thereby reducing the effect of gastric acid and pepsin on the gastric mucosa. damage.

2. Anti-Helicobacter pylori

Chitosan has a broad-spectrum antibacterial effect, which can effectively inhibit the growth of Helicobacter pylori; chitosan can destroy the morphology and ultrastructure of bacteria and ultimately inhibit the growth of Helicobacter pylori. After the 1% chitosan solution with pH = 6.0 was reacted with Helicobacter pylori for 24 hours, the morphology of Helicobacter pylori was diverse, the cell wall was destroyed, and the internal structure of the bacteria changed. Chitosan may damage the structure, function and permeability of the outer membrane of Helicobacter pylori, so that the bacterial contents leak out, the bacteria rupture, and enter into Helicobacter pylori from the damaged outer membrane, interact with the cytoplasm and disrupt its cytoplasm. Metabolism, and ultimately play an anti-Helicobacter pylori effect.

3. Gastric mucosal protective agent

Chitosan has a certain protective effect on the gastric mucosa. Its protective effect is not a simple mechanical covering, but through the interaction with gastric acid to form a colloidal liquid, which adheres to the gastric wall to form a protective film, and chitosan can also inhibit gastric acid. The stimulation and erosion of the injured surface of the stomach can promote the repair of the injured surface. Due to its strong antibacterial activity and only soluble in weak acid, it is quickly dissolved into a viscous colloid when it enters the stomach and adheres to the ulcer surface, which can not only protect the ulcer tissue, but also exert its medicinal effect. , has a better therapeutic effect on gastric ulcer.

4. Chitosan can be used as drug controlled release material

Chitosan is biocompatible and biodegradable in the human body, so it can be used as a drug controlled release material in anti-gastric ulcer drugs. In addition, chitosan derivatives can also be used as good biological carriers for drug release.

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