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The effect of chitosan oligosaccharide on bone and joint

BZ Oligo

The nutrition of chitosan oligosaccharide on bone and joint:

From the perspective of the occurrence of bone and joints, the key to prevention and treatment is to repair damaged cartilage cells, enhance the regeneration and repair ability of cartilage, and improve the elasticity, compression resistance and wear resistance of cartilage. Experiments found that chitosan oligosaccharide has a certain nutritional and repairing effect on bone and joint.

Chitooligosaccharide is composed of glucosamine molecular links, which can be partially degraded into D-glucosamine after entering the human body. Glucosamine is one of the main components of connective tissue and chondrocytes. It can provide nutrition for repairing damaged cartilage cell sugar chain structure, promote the proliferation of chondrocytes, accelerate the synthesis of extracellular matrix, and help maintain bone and joint function. On the other hand, chitosan oligosaccharide can increase the activity of alkaline phosphatase in osteoblasts, induce the production of a special antigen, promote the transformation and catalytic expression of tissue-type plasminogen, promote the growth of osteoblasts, and inhibit the destruction of osteoblasts. The activity of bone multinucleated cells reduces the loss of bone mass.

Chitosan oligosaccharide for the repair of bone trauma:

With the advancement of biological science and technology and the in-depth study of chitosan oligosaccharide, the role of chitosan oligosaccharide in promoting fracture healing has also been found. American scholars in the "Biomaterials Science" magazine published the "early analysis and expression research of chitosan oligosaccharide by cDNA and RT-PCR technology gene research" reported that chitosan oligosaccharide can significantly improve the activity of osteoblast alkaline phosphatase. Through further study of its gene expression, it was found that chitosan oligosaccharide also induced the expression of CD56 antigen and tissue plasminogen catalyzed expression. The activities of these two types of substances are related to the proliferation and differentiation of osteoblasts, which can explain part of the mechanism of chitosan oligosaccharide regulating the growth of osteoblasts and protecting bone and joints.

Activation of osteoblasts is beneficial to accelerate fracture healing. Osteoblasts are the source of new bone production, and their increased number and activity can promote early fracture healing. According to Zhang Wei, Shen Ruowu and others published in Qilu Medical Journal "Effect of chitosan oligosaccharide on bone morphogenetic protein (BMP) in fractured osteoblasts", under experimental conditions, chitosan oligosaccharide activates BMP in fractured osteoblasts. expression to accelerate fracture healing. BMP is secreted by osteoblasts and is a group of multifunctional cytokines in the transforming growth factor family. Its main biological function is to induce the differentiation and proliferation of undifferentiated mesenchymal cells, bone marrow stromal cells and periosteal cells into osteoblasts and chondrocytes. , plays an important role in fracture healing.

Shen Ruowu, Wang Shoubiao, etc. published the article "The Effect of Chitosan Oligosaccharide on Fracture Healing" published in "Journal of Anatomy", which confirmed the promoting effect of chitosan oligosaccharide on fracture healing from another aspect. In their experiments, they found that chitosan oligosaccharide can promote the expression of "transforming growth factor beta-1 for collagen formation" after entering the human body. This transforming growth factor has a variety of biological effects in the repair and renewal of tissue damage. The content of this factor is the most abundant in bone and platelets, which can promote the formation of collagen and is beneficial to fracture healing.

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