Article

The mannuronic oligosaccharide against Alzheimer's disease

Alginate is a linear block compound formed by β- Mannuronic oligosaccharides and α- Guluronate Oligoscharcharide linked by 1 à 4 glycoside bond. There are three kinds of structural fragments, namely PM fragment, PG fragment and PMG fragment. Among them, a series of mannuronic oligosaccharides can be prepared by degradation of polymannose uronic acid (PM).

 

Alzheimer's disease (AD), also known as senile dementia, is mainly manifested in the decline of cognitive and memory function, accompanied by a variety of behavioral disorders, daily life is basically unable to take care of itself. Soluble β-amyloidin (Aβ) aggregates to form insoluble fibers outside nerve cells, and finally precipitates to form aged plaques. Moreover, Aβfibers, whether oligomers or fibers, cause damage to neurons. Therefore, Aβ is one of the important pathological causes of AD. In addition, the hyperphosphorylation of Tau protein makes it dissociate from microtubule and loses its regulation on microtubule, which makes the normal assembly of microtubule impossible. Moreover, the hyperphosphorylation of Tau protein dissociated from microtubule results in the formation of phf-tau, and the formation of nerve fiber tangle (NFT), which results in the loss of basic morphology of neurons, and the neurotoxicity of Tau protein also occurs in the process of self-aggregation. This is also an important reason for the formation of AD. In addition, ad is also associated with many factors, such as aging, oxidative stress, glial inflammation, autophagy, mitochondrial disorder and so on.

The mannuronic oligosaccharide can not only inhibit Aβ aggregation in vitro, but also eliminate overexpression of Aβ, starch like precursor protein (APP) and β secretase (BACE1) in N2a-sw-APP695 cells by autophagy, and maintain cell homeostasis.  In addition, manuronic oligosaccharide can effectively inhibit the aggregation of tau protein induced by heparin in vitro. Inhibiting the aggregation of tau protein can not only reduce the toxicity of tau protein aggregation into polymer structure, but also increase the content of tau protein monomer and promote the stability of microtubule. Mannuronic oligosaccharide can decrease the phosphorylation level of tau protein at position 202、262、396、404 of serine, which indicates that mannuronic oligosaccharide plays an active role in stabilizing microtubule and inhibiting tau protein aggregation. And the mannuronic  oligosaccharide can also effectively reduce the phosphorylation level of the tau protein in the primary neuron of the hek293/ tau cell and the 3-tg mouse, and simultaneously improve the autophagy level of the primary neuron of the 3-to-tg mouse. The mannuronic oligosaccharide thus has the potential to antagonize the neurodegeneration, especially AD.

0 Comments
Leave a Comment
Your email address will not be published. Required fields are marked *
Submit Comment
People also viewed Of
Mechanism of antiviral action and structure-activity relationship of Marine polysaccharide sulfate Application of Chitosan Flocculant in Purification of Traditional Chinese Medicine Application of Chitosan in Food Brown algae oligosaccharide improves drought resistance of wheat Production Process of Chitosan Oligosaccharide The difference between Chitin, Chitosan and Chitosan oligosaccharide Application of chitosan oligosaccharide in potato cultivation Application of Chitosan oligosaccharide in agriculture--Regulate defense responses of plants Good news!Our marine oligosaccharide standard products won the national standard sample certification! Chitosan Oligosaccharide can prolong fruit storage Application of chitosan oligosaccharide in improving fruit quality Application of COS in seed soaking Application of COS in promoting seedling growth Effect of Foliar Spraying of Chitosan Oligosaccharide on Growth and Yield of Chinese Cabbage Chitotriose Trihydrochloride Effects of chitosan oligosaccharides on cold resistance of plants A new environmental protection plant regulator--Chitosan oligosaccharide Carrageenan oligosaccharide with antiviral activity The prebiotic effect of Neoagarooligosaccharides Antioxidant activity of polymannodic and polygulonic Application of Chitooligosaccharides in Aquaculture Bioactivity of chitosan oligosaccharides with different polymerization degrees Immunomodulatory effect of mannuronic oligosaccharides Alginate oligosaccharide elicitor induces tobacco resistance to low temperature Effect of Chitooligosaccharides on Cotton Growth and Yield Effects of alginate oligosaccharides on germination and physiological characteristics of barley seeds Effect of Chitooligosaccharide Seed Dressing on the Germination of Flax Seeds Effect of Chitooligosaccharides on the Fresh-keeping Effect of Chilled Beef Effect of mannuronic oligosaccharides on H2O2 induced senescence of cardiomyocytes Induction of Agaro-oligosaccharide on the resistance of Porphyra haitanensis Effect of Chitooligosaccharides of Different Molecular Weight on Cold Resistance of Cucumber Plug Seedlings Effects of Chitooligosaccharides on Pepper Seed Germination and Seedling Antioxidant Enzyme Activities Study on the effect of oligochitosan on the cold resistance of eggplant seedlings Effect of Chito-oligosaccharide Coated Paper Packaging on Postharvest Freshness of Broccoli Effect of Alginate Oligosaccharide on Soybean Seed Germination and Seedling Physiology Effects of Alginate Oligosaccharides on Soybean Seed Germination and Seedling Physiology Effect of Alginate Oligosaccharide on Sorghum Seed Germination and Seedling Physiological Characteristics Inhibition of water-soluble chitosan on several common bacteria Effect of Agar Oligosaccharide on Cucumber Resistance and Acetamiprid Residue Study on the Application Effect of Alginate Oligosaccharide in Agriculture Study on the anti-obesity activity of oligochitosan Research and Application of Chitooligosaccharides in Fish Feed Application of Chitosan in Beef and Its Products Application method of chitosan oligosaccharide in vegetables and fruits for disease prevention and resistance The function and application skills of plant vaccine chitosan oligosaccharide Effects of Chitooligosaccharide on Pregnant Sows and Lactating Sows The good partner of the gut - Alginate oligosaccharide Alginate oligosaccharide enhances plant resistance to Phytophthora infestans Effects of Alginate Oligosaccharide on Stress Resistance of Rice Seedlings under Salt Stress Study on free radical scavenging activity of agar oligosaccharide in vitro Application of Carboxymethyl Chitosan in Daily Cosmetics Protective effect of chitosan oligosaccharide on acetaminophen-induced liver injury Effects of chitosan oligosaccharide on the growth, immunity and intestinal flora of tiger dragon spots Effects of chitosan oligosaccharides on the quality of biscuits and cakes Ameliorative effect of Alginate Oligosaccharide on ovarian insufficiency in mice Application of carrageenan and its oligosaccharides in the field of biomedicine The mechanism of action of chitosan oligosaccharide against nematodes How does chitosan oligosaccharide protect the liver? Application of Chitosan in Food Field Research progress of chitosan in gastric ulcer medicine Chitosan can improve aquaculture water for aquatic animals Effects of Chitooligosaccharide Treatment on Storage Quality of Strawberry Effects of Chitooligosaccharide and Lactobacillus casei on Growth Performance of Weaned Piglets The effect of chitosan oligosaccharide on bone and joint 【BZ Oligo - Power of Innovation】The improvement effect of Alginate oligosaccharide on ovarian insufficiency in mice Effects of chitosan oligosaccharides with different degrees of polymerization on the germination of soybean seeds Study on κ/β-carrageenan oligosaccharide for diabetic skin repair Alginate Oligosaccharide relieves heavy metal toxicity The role of chitosan oligosaccharide in feed Absorption distribution of chitosan oligosaccharide monomers with different degrees of polymerization in mice Chitooligosaccharide and chitosan as the basic conditions of functional health food The role of chitosan oligosaccharide and chitosan in aquatic feed Anti-inflammatory and antioxidant effects of chitosan oligosaccharide The application and case of alginate oligosaccharide in agriculture The biological mechanism of action of chitosan oligosaccharide and chitosan Chitooligosaccharide for the treatment of ulcerative colitis The mechanism of chitosan oligosaccharide and chitosan in preventing and treating liver disease The effect of Alginate Oligosaccharide on the growth of oval pomfret trevally seedlings Application effect of chitosan oligosaccharide in animals Effects of Chitooligosaccharides on Soil Microorganisms Chitosan oligosaccharide against intestinal inflammation Anti-osteoporosis effect of alginate oligosaccharides Effects of chitosan oligosaccharide supplementation on the immune function of adult cats Alginate oligosaccharide prevents doxorubicin cardiotoxicity The function and application skills of plant vaccine chitosan oligosaccharide Neuroprotective effect of agar oligosaccharide Effects of Chitooligosaccharide Relieving Salt Stress on Cabbage Seedlings Chitosan and chitosan oligosaccharides are good news for patients with gastrointestinal diseases Compatibility experiment of carboxymethyl chitosan and surfactant Induction of resistance of chitosan oligosaccharide to Fusarium wilt of bitter gourd Precautions and side effects of taking chitosan oligosaccharide and chitosan Which polymerization degree of chitosan oligosaccharide monomer has the best anti-tumor effect? Effects of Chitosan Oligosaccharides on Meat Rabbits Treatment of acute radiation enteritis by intragastric administration of chitosan oligosaccharide Chitosan film coating prolongs the shelf life of sweet cherries Chitosan oligosaccharides and chitosan can reduce and prevent hyperlipidemia Application of chitosan in fruit preservation Application of chitosan in the preservation of meat and eggs Chitooligosaccharides against Shigella Protective effect of chito-oligosaccharides on liver injury induced by acetaminophen Alginate Oligosaccharide protects intestinal health Characterization of effects of chitooligosaccharide monomer addition on immunomodulatory activity in macrophages Chitosan oligosaccharide alleviates the growth inhibition caused by physcion and synergistically enhances resilience in maize seedlings A Meta-analysis of chitosan oligosaccharides Exogenous application of coronatine and alginate oligosaccharide to maize seedlings enhanced drought tolerance at seedling and reproductive stages Chitin Oligosaccharide and Chitosan Oligosaccharide Nuclear calcium oscillations induced by chitin oligomers Alginate Oligosaccharides Repair Liver Injury Chitosan oligosaccharide is used to prepare cellulosic fibers with antibacterial and antiviral performance Intranasal H5N1 Vaccines, Adjuvanted with Chitosan Derivatives, Protect Ferrets against Highly Pathogenic Influenza Intranasal and Intratracheal Challenge Alginate oligosaccharide and cyanidin-3-O-glucoside synergistically improve intestinal function Antidiabetic Properties of Chitosan and Its Derivatives Chitosan increases Pinus pinaster tolerance to the pinewood nematode [The Ocean University of China Zhao Xia Research Group] Seaweed Polysaccharide Photodynamic Thermosensitive Hydrogel Accelerates Healing of Infected Wounds The Impacts of Chitosan Oligosaccharide on Tomoto Quality How does alginate oligosaccharides improve Sperm Quality in young patients with Type 2 diabetes? Stimulation of human keratinocyte growth by alginate oligosaccharides Synergy of fungicide activities by Alginate oligosaccharides Chitosan oligosaccharide improves the Function of ovarian granulosa cells Pharmacokinetics of COS Application of functional oligosaccharides in sows Calcium-absorption enhancing effect of COS Chitopentaose Pentahydrochloride The mechanism of alginate oligosaccharides as plant growth promotors Chitosan oligosaccharides alleviate kidney damage in prediabetic rats The mechanisms involved in the growth-promoting efects of AOS A new way to treat colitis OligoG enhance the antifungal activity of nystatin against candidal biofilms Chitosan oligosaccharides may be used to treat ischemic diseases of lower limbs The synergetic effect of AOS and algal β-glucan in reducing intestinal inflammation The team of Huazhong Agricultural University analyzed the cellular and molecular mechanism of chito-oligosaccharides enhancing humoral immunity of fish Chitosan oligosaccharide as a plant immune inducer on the Passiflora spp. CMV disease Application of chitosan oligosaccharides in dough AOS application improve fruit sugar accumulation and quality in citrus Combined Transcriptome and Metabolome Analysis of Alginate Oligosaccharides Alleviating Salt Stress in the Rice Seedling Stage Exogenous Chitosan Oligosaccharide Improved Cold Tolerance in Cucumber Synergistic effect of chitooligosaccharides Chitosan oligosaccharides increased artemisinin yield under drought stress Combined application of oligochitosan and Pichia carrbbica improves the disease resistance of postharvest tomato fruits Influence of dietary chitosan-oligosaccharides supplementation on productive and reproductive performance of laying hens the Effect of Chitosan oligosaccharides on Tea Plant Growth and Yield One of the weight-loss mechanisms of chito-oligosaccharides the protective role of COS in germ cell damage Mechanism of chitosan oligosaccharides in prevention and treatment of colitis Alginate oligosaccharide improves resistance to postharvest decay and quality in kiwifruit Alginate oligosaccharides increase boar semen quality by affecting gut microbiota and metabolites in blood and sperm
People who viewed this item also viewed
Concact Us Now
Chitosan Oligosaccharide, Alginate Oligosaccharide, Chitosan Oligosaccharide Suppliers - BZ Oligo
No.596, Jiushui East Road, Biomedical Industry Park, Laoshan District, Qingdao, China
You can trust us
We are a professional Manufacturer in China, and we are constantly innovating so that our customers can have better products and services.
© 2018 Gobalsir Inc.        SiteMap.html    SiteMap.xml    Terms of Service      Privacy Policy
Marketing Support by Globalsir
Enter your inquiry details, We will reply you in 24 hours.
Name can't be empty
E-mail can't be empty
Company can't be empty
Phone can't be empty
Products can't be empty
Message can't be empty
Verification code error
code
Clear